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Recent Scientific Publications

2011

  • "TAK-960, an investigational novel, orally available, selective inhibitor of Polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple does regimens" Mol. Cancer Ther. published online 21-Dec-2011 | Pubmed
  • "Two-dimensional supercritical fluid chromatography / mass spectrometry for the enantiomeric analysis and purification of pharmaceutical samples" J. Chromatogr. A 1218 (2011) 3080-3088 | Pubmed
  • "A Strategic Approach for the Determination of Biosensor Regeneration Conditions" J Immunol Methods. 2011 Aug 31;371(1-2):165-9. Epub 2011 Jun 17 | Pubmed
  • "T7 Lytic Phage-Displayed Peptide Libraries: Construction and Diversity Characterization" Methods in Molecular Biology: Therapeutic Peptides
  • "Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2" published on line J.Biol.Chem on 30-Mar-2011. | Pubmed
  • "Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer" Bioorg Med Chem Lett. 2011 Mar 1;21(5):1315-9. Epub 2011 Jan 22. | Pubmed
  • Synthetic approaches to 1,8-napthyridine-2,5-dione compounds Tetrahedron Letters 52 (2011) 477-479
  • Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV J Med Chem. 2011 Jan 27;54(2):510-524. Epub 2010 Dec 27 | Pubmed

2010

  • "Application of Quantitative Pharmacology in the Design of First-In-Human Dosing Strategy for Development of Antibody-Based Therapeutics" AAPS J. 2010 Dec;12(4):592-601. Epub 2010 Jul 24. | Pubmed
  • "Structure-Based Design and Synthesis of Pyrrole Derivatives as MEK Inhibitors" Bioorg. Med. Chem. Lett. 2010, 20(14), 4156-4158 | Pubmed
  • "Development of a high-throughput online solid-phase extraction/tandem mass spectrometry method for cytochrome P450 inhibition screening" J Biomol Screen. 2010 Apr;15(4):447-52 | Pubmed
  • "Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity" Bioorg Med Chem Lett. 2010 May 15;20(10):3138-41 | Pubmed
  • "Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides" Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5 | Pubmed
  • "Intramolecular Diels-Alder synthesis of 7-aza-alpha-carboline compounds" Tetrahedron Letters 51 (2010) 1739-1741 | ChemInform
  • "A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry" J Chromatogr A. 2010 Mar 5;1217(10):1616-25 | Pubmed
  • "Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects" Int J Clin Pharmacol Ther. 2010 Jan;48(1):46-58 | Pubmed
  • "Metabolomics Based Discovery of Diagnostic Biomarkers for Onchocerciasis" PLoS Negl Trop Dis 2010, 4 (10), e834 | Pubmed